بررسی تأثیر تحرک زودرس بر شاخص‌ استرس اکسیداتیو در بیماران تحت آنژیوگرافی عروق کرونر: یک مطالعه کارآزمایی بالینی تصادفی
  •   آرشیو : نسخه تابستان 1405 - جلد دوم
  •   کد پذیرش : 141224
  •   موضوع : سایرشاخه‌ها
  • نویسنده/گان : | سارا شمس‌الدینی، زهرا ملازم، مجید نجفی کلیانی، مانی حسن‌زاده
  •   زبان : فارسی
  •   نوع مقاله : پژوهشی
  •   چکیده مقاله به فارسی : مقدمه: افزایش تولید رادیکال‌های آزاد بدنبال استرس های جسمی سبب ایجاد استرس اکسیداتیو می شود. مراقبت های پس از آنژیوگرافی کرونر از جمله بیحرکتی و گذاشتن کیسه شن به منظور کاهش تحرک در بسیاری از بیماران سبب خستگی و کمر درد می شود. با توجه به بی حرکتی بیماران و مشکلات جسمی، این مطالعه با هدف بررسی تأثیر تحرک زودرس بر میزان مالون دی آلدهید بعنوان یکی از شاخص های استرس اکسیداتیو در بیماران تحت آنژیوگرافی عروق کرونر انجام گرفت. روش کار: در این مطالعه کارآزمایی بالینی تصادفی 50 نفر از بیماران تحت آنژیوگرافی عروق کرونر به صورت ‌تصادفی به دو گروه مداخله (25 نفر) وگروه کنترل (25 نفر) تخصیص یافتند. در گروه مداخله، مدت زمان گذاشتن کیسه شن از 6 ساعت به 4 ساعت کاهش یافت. در گروه کنترل مراقبت روتین (گذاشتن کیسه شن به مدت 6 ساعت) انجام شد. قبل از آنژیوگرافی و 6 ساعت بعد از انجام آن، میزان مالون دی آلدهید با گرفتن نمونه خون و با استفاده از کیت استاندارد اندازه‌گیری شد. آنالیز داده‌ها با استفاده از نرم‌افزار SPSS نسخه 22 و با کمک آزمون‌های آماری تی مستقل، تی زوجی، آنوا و کای اسکوئر انجام شد. یافته‌ها: نتایج مطالعه نشان داد که دو گروه مداخله و کنترل از نظر متغیرهای زمینه‌ای و دموگرافیک اختلاف معناداری ندارند (05/0
  •   لیست منابع : [1] Tavakol M, Ashraf S, Brener SJ. Risks and complications of coronary angiography: a comprehensive review. Global journal of health science. 2012;4(1):65.
    [2] SC. S, BG. B, JL. H, KH. C. Brunner and Suddarth's Textbook of Medical Surgical Nursing: In One Volume: Lippincott Williams & Wilkins. 2010.
    [3] Naseri Salahshour V. The Effect of Body Position and Early Ambulation on Comfort, Bleeding, and Ecchymosis After Diagnostic Cardiac Catheterization. Journal of Client-Centered Nursing Care. 2017;3(1):19-26.
    [4] Abdollahi AA, Mehranfard S, Behnampour N, Kordnejad AM. Effect of positioning and early ambulation on coronary angiography complications: a randomized clinical trial. Journal of caring sciences. 2015;4(2):125.
    [5] Steffenino G, Dutto S, Conte L, Dutto M, Lice G, Tomatis M, et al. Vascular access complications after cardiac catheterisation: a nurse-led quality assurance program. European Journal of Cardiovascular Nursing. 2006;5(1):31-6.
    [6] MeharanFard S, Abdollahi A, BehnamPour N, KordNejad A. Correlated Factors with Back Pain in Patients after Coronary Angiography. JOURNAL OF RESEARCH DEVELOPMENT IN NURSING & MIDWIFERY. 2013;9(2):20-6.
    [7] Elliott D, Aitken L, Chaboyer W. Critical care nusing. Australia. Elsevier; 2007.
    [8] Sabzaligol M, Shariat E, Varaei S, Mehran A, Bassampour S. The Effect of Changing Position and Early Ambulation after Cardiac Diagnostic Catheterization on Back pain and Bleeding. Hayat. 2011;15(4).
    [9] A. E, M. F, M. N, A. BZ, A. KZ, M. NK, et al. The Frequency of Oxidative Stress Indexes after Endotracheal Suction in CABG Patients which Hospitalized in Jamaran Heart Hospital of Tehran. JRUMS. 2008;7(2):131-6.
    [10] Possik E, Pause A. Measuring oxidative stress resistance of Caenorhabditis elegans in 96-well microtiter plates. JoVE (Journal of Visualized Experiments). 2015(99):e52746.
    [11] Miri MM, Mohammadi P. Evaluation of oxidative stress biomarkers in patients with medullary thyroid carcinoma and compared to healthy subjects. Journal of Military Medicine. 2017;19(1):84-90.
    [12] Arsova-Sarafinovska Z, Dimovski AJ. Natural antioxidants in cancer prevention. Macedonian pharmaceutical bulletin. 2013;59(1, 2):3-14.
    [13] Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition. 2017;14(1):24.
    [14] F. H, M. F, S. Z. The role of oxytocin on cardiac ischemia-reperfusion-induced oxidative stress in RAts. Iranian Journal of Endocrinology and Metabolism. 2011;12(6):633-40.
    [15] F. K-K, N. M. Association of OX-LDL and MDA Serum Level with Extent of Coronary Artery Disease. aumj. 2016;5(4):229-35.
    [16] Vatany;K. K, Haghparast;F., Eftekhar;E., Noroozzadeh;j. Pro oxidant and antioxidant status in patients with coronary artery disease proven angiographic ally. Hormozgan Medical Journal. 2009;12(4):231-6.
    [17] Sheikh;N., Esfahani.M, Nazari;L. H, Safari;M., Koraki;M. The effect of hemodialysis on changes in lipid peroxidation. Asrar. 2007;14(2):89-94.
    [18] Najafi Mehri S. Biomarkers-based research in nursing. Iranian Journal of Critical Care Nursing. 2009;2(3):121-5.
    [19] Mohammadian;M. A, Kazemnegad;E., R. F, Moghadamnia;M., Salari;A. The effect of rest period on bed and duration of sandbag keeping on the incidence of hemorrhage and hematoma in patients undergoing coronary angiography. journal of HOLISTIC NURSING AND MIDWIFERY. 2011;21(2):1-6.
    [20] Boomi Ghuchane Atigh M, Malekaneh M, Mashreghi Moghaddam H, Anani Sarab G. Evaluation of oxidative stress and homocysteine level in patients with acute myocardial infarction: a case-control study. J Birjand Univ Med Sci. 2016;23(2):141-8. Available from: http://journal.bums.ac.ir/article-1-2034-en.html.
    [21] Wang J, Ren D, Liu Y, Wang Y, Zhang B, Xiao Q. Effects of early mobilization on the prognosis of critically ill patients: A systematic review and meta-analysis. International Journal of Nursing Studies. 2020;110:103708. Available from: https://www.sciencedirect.com/science/article/pii/S0020748920301942.
    [22] Ruegsegger GN, Booth FW. Health Benefits of Exercise. Cold Spring Harb Perspect Med. 2018;8(7).
    [23] Niknam Sarabi H, Farsi Z, Butler S, Pishgooie AH. Comparison of the effectiveness of position change for patients with pain and vascular complications after transfemoral coronary angiography: a randomized clinical trial. BMC Cardiovasc Disord 2021;21(1):114. Available from: https://doi.org/10.1186/s12872-021-01922-w.
    [24] Abdollahi AA, Mehranfard S, Behnampour N, Kordnejad AM. Effect of positioning and early ambulation on coronary angiography complications: a randomized clinical trial. J Caring Sci. 2015;4(2):125. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484987/.
    [25] Kor A, Yazdi K, Abdollahi AA, Behnampour N. Effect of changing sandbag weight on complications of femoral artery catheterization and patients comfort: A clinical trial study. Journal of Gorgan University of Medical Sciences. 2021;22(4):23-9. Available from: http://goums.ac.ir/journal/article-1-3740-en.html.
    [26] Höglund J, Stenestrand U, Tödt T, Johansson I. The effect of early mobilisation for patient undergoing coronary angiography; a pilot study with focus on vascular complications and back pain. Eur J Cardiovasc Nurs. 2011;10(2):130-6.
    [27] Sties SW, Andreato LV, de Carvalho T, Gonzáles AI, Angarten VG, Ulbrich AZ, et al. Influence of exercise on oxidative stress in patients with heart failure. Heart Fail Rev. 2018;23(2):225-35.
    [28] Gardner AW, Montgomery PS, Zhao YD, Silva-Palacios F, Ungvari Z, Csiszar A, et al. Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease. Journal of vascular surgery. 2017;65(6):1762-8.
    [29] Nourooz Zadeh J, Eftekhar E, Haghparast F, Khademwatan K, Ekhlasmand M. Evaluation of Measures of Oxidative Stress in Patients with Proven Coronary Artery Disease (CAD) Compared with Normal Persons. J Adv Med Biomed Res. 2007;15(60):47-56. Available from: http://zums.ac.ir/journal/article-1-234-en.html.
    [30] Tariq MI, Khan AA, Khalid Z, Farheen H, Siddiqi FA, Amjad I. Effect of Early ≤ 3 Mets (Metabolic Equivalent of Tasks) of Physical Activity on Patient's Outcome after Cardiac Surgery. J Coll Physicians Surg Pak. 2017;27(8):490-4.
    [31] Hussein Ahmed H. The Effect of Early Ambulation on Hemodynamic and Perfusion Indices Post Cardiac Surgery. American Journal of Nursing Research. 2021;7(4):490-8. Available from: http://pubs.sciepub.com/.
    [32] Dani C, Proen, #231, a I, Marinho J, Peccin P, et al. Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease. Neural Regeneration Research. 2020;15(11):2067-72. Available from:
    http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2067;epage=2072;aulast=Dani.
    [33] Farmanbar R, Chinikar M, Gozalian M, Baghaie M, Roshan ZA, Moghadamnia M. The effect of post coronary angiography bed-rest time on vascular complications. The Journal of Tehran University Heart Center. 2008;3(4):225-8.
    [34] Magherini F, Fiaschi T, Marzocchini R, Mannelli M, Gamberi T, Modesti PA, et al. Oxidative stress in exercise training: the involvement of inflammation and peripheral signals. Free Radic Res. 2019;53(11-12):1155-65.
    [35] Lu Z, Xu Y, Song Y, Bíró I, Gu Y. A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis. Front Physiol. 2021;12:700055.
  •   کلمات کلیدی به فارسی : آنژیوگرافی عروق کرونر، تحرک زودرس، استرس اکسیداتیو، مالون دی آلدهید.
  •   چکیده مقاله به انگلیسی : Introduction: Increased production of free radicals following physical stress leads to oxidative stress. Post-coronary angiography care, including immobilization and the use of sandbags to restrict movement, often causes fatigue and back pain in many patients. Given the immobilization and associated physical discomfort, this study aimed to investigate the effect of early mobilization on the levels of malondialdehyde (MDA), as a marker of oxidative stress, in patients undergoing coronary angiography. Methods: In this randomized clinical trial, 50 patients undergoing coronary angiography were randomly allocated into an intervention group (n=25) and a control group (n=25). In the intervention group, the duration of sandbag application was reduced from 6 hours to 4 hours. The control group received routine care (sandbag application for 6 hours). Malondialdehyde levels were measured using standard kits from blood samples taken before angiography and 6 hours post-procedure. Data were analyzed using SPSS software (version 22) and statistical tests including independent t-test, paired t-test, ANOVA, and Chi-square. Results: The results showed no significant difference between the intervention and control groups regarding baseline and demographic variables (p > 0.05). Before the intervention, the mean malondialdehyde levels in the intervention group (33.0 ± 9.68) and the control group (31.69 ± 12.01) did not differ significantly (p = 0.63). After the intervention, there was also no significant difference in the mean malondialdehyde levels between the intervention group (31.74 ± 10.34) and the control group (30.49 ± 10.86) (p = 0.80). Conclusion: Based on the findings of this study, reducing the duration of bed rest from 6 hours to 4 hours does not significantly affect malondialdehyde levels as a marker of oxidative stress in patients undergoing coronary angiography. Therefore, further studies are recommended in this field.
  •   کلمات کلیدی به انگلیسی : Coronary Angiography, Early Mobilization, Oxidative Stress, Malondialdehyde
  •  صفحات : 104-115
  •   دانلود فایل ( 1,015.98 KB )